DNA ligases seal five′-PO4 and three′-OH polynucleotide ends by using 3 nucleotidyl transfer actions involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are important guardians of genomic integrity, and ligase dysfunction underlies human genetic sickness syndromes. Crystal structures of DNA ligases certain to nucleotide and nucleic acid substrates have illuminated https://georgesu234gas8.livebloggs.com/profile