The recognized impact of such PTMs on ATXN2’s operate and SCA2 pathogenesis remains limited. In other polyQ illnesses, numerous research suggested that proteolytic cleavage of polyQ proteins could Participate in an important part in pathogenesis [36, 45]. Aligned with this particular idea, the presence of the enriched forty two kDa fragment https://joshp909hsc2.digitollblog.com/profile