Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other signals in the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have recognized recurrent mutations in genes regulating tumor cell-microenvironment interactions... https://quentinl542oyy8.blogpayz.com/profile