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Opioid activity is because of each low affinity binding of your guardian compound and better affinity binding in the O-demethylated metabolite M1 to µ-opioid receptors. In animal versions, M1 is nearly six periods much more potent than tramadol in manufacturing analgesia and 200 moments far more potent in µ-opioid binding. https://codeinephosphate30mg03467.imblogs.net/82314816/the-fact-about-codeine-phosphate-30mg-price-that-no-one-is-suggesting

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