Epidural clonidine applied as an adjunct to area anesthetics has 3 unique mechanisms of action. 1st, the stimulation of alpha-2-receptors during the dorsal horn reduces pain transmission. Next, clonidine could potentially cause regional vasoconstriction that limits vascular elimination of nearby epidural anesthetics. For those who get dizzy when standing: https://vona340uoi8.blogvivi.com/profile